李思颖

E-Mail：lisiying@sdu.edu.cn

◆教育背景

2010/09-2015/06，山东大学医学院，免疫学，博士

2003/08-2010/08，山东大学医学院，临床医学，本硕连读

◆工作经历

2017/11-至今，山东大学基础医学院病理生理学系，助理研究员

2015/09-2017/09，山东大学药学院，药物制剂与释药系统研究中心，博士后

2011/04-2013/09，美国南卡罗来纳州立大学医学院，访问学者

◆科研方向

Ø 硫化氢在心衰与心肌重塑中的作用。

Ø 自噬在肿瘤发生及相关抗肿瘤药物中的作用研究。

◆发表文章

1. Siying Li, Guang Yang, Xiaosong Zhu, Lin Cheng, Yueyue Sun, Zhongxi Zhao.

Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cells apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway. Oncology Reports 2017(38): 1637-1644.（第一作者）

2. Weizhen Huang, Yongjie Wang, Xiaoyan Jiang, Yueyue Sun, Zhongxi Zhao#, Siying Li#. Protective Effect of Flavonoids from Ziziphus jujuba cv. Jinsixiaozao against Acetaminophen-Induced Liver Injury by Inhibiting Oxidative Stress and Inflammation in Mice. Molecules 2017, 22(10): E1781.（共同通讯作者）

3. Xiaosong Zhu, Xiaoyan Jiang, Ang Li, Yueyue Sun, Yan Liu, Xiao Sun, Xiuli Feng, Siying Li#, Zhongxi Zhao#. S-allylmercaptocysteine suppresses the growth of human gastric cancer xenografts through induction of apoptosis and regulation of MAPK and PI3K/Akt signaling pathways. Biochemical and Biophysical Research Communications 2017: 1-6.（共同通讯作者）

4. Xiaoyan Jiang, Xiaosong Zhu, Weizhen Huang, Hongya Xu, Zhongxi Zhao#, Siying Li#, Shanzhong Li, Jianhua Cai, Jimin Cao. Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice. International Immunopharmacology 2017(48):135-145.（共同通讯作者）

5. Xiao-yan JIANG, Xiao-song ZHU, Hong-ya XU, Zhong-xi ZHAO#, Si-ying LI#, Shan-zhong LI, Jian-hua CAI, Ji-min CAO. Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer treatment. Acta Pharmacologica Sinica 2017: 1–11.（共同通讯作者）

6. X. Zhu, X. Jiang, A. Li, Z. Zhao#, S. Li#, S-Allylmercaptocysteine Attenuates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation, Nutrients, 2017, 9(2). （共同通讯作者）

7. X. Jiang, X. Zhu, N. Liu, H. Xu, Z. Zhao#, S. Li#, S. Li, J. Cai, J. Cao. Diallyl Trisulfide Inhibits Growth of NCI-H460 in Vitro and in Vivo, and Ameliorates Cisplatin-Induced Oxidative Injury in the Treatment of Lung Carcinoma in Xenograft Mice. International Journal of Biological Sciences, 2017, 13(2): 167-178. （共同通讯作者）

8. Wang Y., Qi Q., Li A., Yang M., Huang W., Xu H., Zhao Z.#, Li S.#. Immuno-enhancement effects of YifeiTongluo Granules on cyclophosphamide-induced immunosuppression in Balb/c mice. Journal of Ethnopharmacology 2016, 194: 72-82.（共同通讯作者）

9. Yang M., Wang Y., Zhang Y., Zhang F., Zhao Z.#, Li S.#, Zhang J., Cao X., Zhang D., S-allylmercapto-L-cysteinemodulates MUC5AC and AQP5 secretions in a COPD model via NF-кB signaling pathway. International Immunopharmacology 2016, 39: 307-313.（共同通讯作者）

10. Li S*, Wang W*, Niu T, Wang H, Li B, Shao L, Lai Y, Li H, Janicki JS, Wang XL, Tang D, Cui T. Nrf2 deficiency exaggerates doxorubicin-induced cardiotoxicity and cardiac dysfunction. Oxid Med Cell Longev 2014: 748524.（共同第一作者）

11. Wang W, Li S*, Wang H, Li B, Shao L, Lai Y, Horvath G, Wang Q, Yamamoto M, Janicki JS, Wang XL, Tang D, Cui T. Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins. J Mol Cell Cardiol 2014, 72: 305-315. （共同第一作者）

12. Heng-cai YU*, Si-ying LI*, Ming-feng CAO, Xiu-yun JIANG, Li FENG, Jia-jun ZHAO, Ling GAO. Effects of chronic ethanol consumption on levels of adipokines in visceral adipose tissues and sera of rats. Acta Pharmacologica Sinica 2010; 31: 461–469.（共同第一作者）

13. Guang Yang, Siying Li, Bin Li, Lin Cheng, Peng Jiang, Zhoubin Tian, Shui Sun. Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1β-Stimulated Chondrocytes by Regulation of MMPs/TIMP-1 Ratio and Type II Collagen Expression via Suppression of NF-κB Pathway. Biomed Res Int 2017:8686207.

14. Wang H, Lai Y, Mathis BJ, Wang W, Li S, et al. Deubiquitinating enzyme CYLD mediates pressure overload-induced cardiac maladaptive remodeling and dysfunction via downregulating Nrf2. J Mol Cell Cardiol 2015, S0022-2828(15)00127-3.

15. Liu S, Lv J, Han L, Ichikawa T, Wang W, Li S, Wang XL, Tang D, Cui T. A pro-inflammatory role of deubiquitinating enzyme cylindromatosis (CYLD) in vascular smooth muscle cells. Biochem Biophys Res Commun. 2012;420(1):78-83.

16. Xing Y, Niu T, Wang W, Li J, Li S, Janicki JS, Ruiz S, Meyer CJ, Wang XL, Tang D, Zhao Y, Cui T.. "Triterpenoid Dihydro-CDDO-Trifluoroethyl Amide Protects against Maladaptive Cardiac Remodeling and Dysfunction in Mice: A Critical Role of Nrf2." PLoS One 2012, 7(9): e44899.

17. Wu, Q, Wang, W, Li, S, et al. "American ginseng inhibits vascular smooth muscle cell proliferation via suppressing Jak/Stat pathway." J Ethnopharmacol 2012, 144(3): 782-785.

◆科研项目

Ø 国家自然科学青年科学基金项目，81800353，硫化氢巯基化修饰自噬相关蛋白Atg4及大蒜有机硫化合物在心衰及心肌重塑中的作用及机制，2019/01-2021/12，主持，在研。

Ø 山东大学基本科研业务费资助项目（人才引进与培养类专项），21510077614098，CYLD调控血管平滑肌细胞表型转化在血管重构中的作用机制，2017/09-2019/12，主持，在研。

Ø 国家自然科学青年科学基金项目，81100064，泛素羧基末端水解酶L1在心脏肥大中的作用及分子机制，2012/01-2014/12，参加，结题。

◆学术会议

2012.9，美国西雅图，第16届美国心衰协会，Joy N. Cohn New Investigator Basic Science Award，Poster Exchange