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王贞

 

王贞,女,自2003年以来在山东大学从事神经发育的研究。对多种因素致神经发育异常的发生机制进行了深入的探索,熟练掌握神经干细胞培养与诱导分化体系、分子生物学、形态学和实验动物学方面的理论和操作。2008.7-2009.12 赴美国肯塔基大学进修学习,主要研究脂类代谢在动脉粥样硬化和神经发育中的作用。目前主要从事研究缺血缺氧性脑损伤、与肥胖有关神经系统疾病,以第一作者或共同第一作者发表高水平SCI论文10篇,以通讯作者发表论文2篇。近年来主持国家课题一项,博士后特别资助课题一项,博士后面上课题一项,省级课题一项,参与及完成国家、省级课题多项。指导了多名大学生获得了山东大学大学生科技创新基金。

代表性论著:

1. Wang Z#, Liu D, Wang J, Liu S, Gao M, Ling EA, Hao A*. Cytoprotective effects of melatonin on astroglial cells subjected to palmitic acid treatment in vitro. Journal of pineal research. 2012 Mar;52(2):253-64IF: 7.304PubMed

2. Wang Z#, Liu D, Zhan J, Xie K, Wang X, Xian X, Gu J, Chen W, Hao A*. Melatonin improves short and long-term neurobehavioral deficits and attenuates hippocampal impairments after hypoxia in neonatal mice. Pharmacological Research. 2013 Oct; 76:84-97. IF: 4.346PubMed

3. Wang Z#, Liu DX, Wang FW, Zhang Q, Du ZX, Zhan JM, Yuan QH, Ling EA, Hao AJ*. L-cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H2S pathway. Neuroscience. 2013, 237:106-117.IF: 3.122PubMed

4. Wang Z#, Liu D#, Wang F, Liu S, Zhao S, Ling EA, Hao A*. Saturated fatty acids activate microglia via Toll-like receptor 4/nuclear factor κB signaling. British journal of nutrition. 2012 Jan;107(2):229-41.IF: 3.446PubMed

5. Wang Z#, Liu D, Zhang Q, Wang J, Zhan J, Xian X, Du Z, Wang X, Hao A*.   Palmitic acid affects proliferation and differentiation of neural stem cells in vitro.  Journal of Neuroscience Research, 2014 Jan 21. doi: 10.1002/jnr.23342IF: 2.974PubMed

6. Wang Z#, Zhan J, Wang X, Gu J, Xie K, Zhang Q, Liu D*. Sodium hydrosulfide prevents hypoxia-induced behavioral impairment in neonatal mice. Brain Res 2013 Nov 13;1538:126-34. IF: 2.879PubMed

7. Wang Z#, Gu J, Wang X, Xie K, Luan Q, Wan N, Zhang Q, Jiang H, Liu D*. Antidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: the HPA axis, BDNF expression and phosphorylation of ERK. Pharmacol Biochem Behav. 2013 Nov;112:104-10. IF: 2.608PubMed

8. Liu D#, Zhang Q, Gu J, Wang X, Xie K, Xian X, Wang J, Jiang H, Wang Z*. Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Mar 3;49:21-9. IF: 3.552PubMed

9. Liu D#, Xie K, Yang X, Gu J, Ge L, Wang X, Wang Z*. Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats. Behav Brain Res. 2014 Feb, 264:9-16.IF: 3.327PubMed

10. Liu D#, Wang Z#, Liu S, Wang F, Zhao S, Hao A*. Anti-inflammatory effects of fluoxetine in lipopolysaccharide (LPS)-stimulated microglial cells. Neuropharmacology. 2011 Sep;61(4):592-9. IF: 4.814PubMed

11. Cai L#, Wang Z#, Ji A, Meyer JM, van der Westhuyzen DR*. Scavenger receptor CD36 expression contributes to adipose tissue inflammation and cell death in diet-induced obesity. PloS one. 2012;7(5):e36785. IF: 4.092PubMed

12. Jiang H#, Wang Z#, Wang Y, Xie K, Zhang Q, Luan Q, Chen W, Liu D* Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action. Prog Neuropsychopharmacol Biol Psychiatry.2013. Dec 2;47:33-9IF: 3.552PubMed

承担课题:

1. 国家自然科学基金青年基金:饱和脂肪酸对胚胎神经系统发育的影响及机制研究,2013.01- 2015.12 第一位 (No. 81200879)

2. 中国博士后科学基金特别资助:硫化氢对缺血缺氧性脑损伤神经系统发育的影响及机制2013.07-2015.07 第一位(No. 2013T60672)

3. 中国博士后科学基金面上资助孕期肥胖对胚胎神经系统发育的影响及机制研究2012.05-2013. 12,第一位(No. 2012M511514)

4. 山东省自然科学基金(青年项目)清道夫受体CD36在脂肪组织脂类代谢和炎症反应中的作用及机制的研究2011.07-2014.07 第一位(No. ZR2011HQ035)

5. 山东大学自主创新基金:硫化氢对神经干细胞增殖分化的影响及其机制研究2013.01-2015.12,第一位(IIFSDU2012TS120)

通讯地址:
邮政编码 250012
山东省济南市文化西路44号山东大学医学院生理学研究所

办公电话:0531-88383902

Email: wangzhen@sdu.edu.cn

 



INSTITUTE of PHYSIOLOGY School of Medicine Shandong University  Address:Baotu Spring campus of Shandong University  Zip Code:250012